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                FKBP38 Antibody, FK506结合蛋白38抗体

                 
                编 号 PR-1023
                产品名称 FKBP38 Antibody, FK506结合蛋白38抗体
                规 格 0.2ml
                价 格 1980元
                应 用 IHC,WB,ELISA,ICC,IP,IF
                品 牌 Hopebiot

                详细信息: 说明书下载

                Background:  FKBP38 (FK506-binding protein 38), a member of the immunophilin family, has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBP38 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes.

                Description: Rabbit polyclonal to FKBP38

                Immunogen: KLH conjugated synthetic peptide derived from FKBP38

                Specificity:  ·Reacts with Human, Mouse, Dog, Cow, Chicken and Rat.

                ·Isotype: IgG

                Application:  ·Western blotting: 1/500-1000. Predicted Mol wt: 45 kDa;

                ·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;

                ·Immunocytochemistry: 1/200;

                ·ELISA: 1/500;

                ·Optimal working dilutions must be determined by the end user.

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